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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Oral Oncol. 2006 Nov 16;43(7):701–712. doi: 10.1016/j.oraloncology.2006.09.001

Table 6.

Variables associated with formation of a cell line

Variable Cell Linea p-valueb Unadjusted OR (95% CI) Adjusted OR (95% CI)c
Y N -
199 52 128 19
p53 status WT 35 74 8 0.637 1.0
mut 9 15 2 1.27 (0.50 − 3.19)
- 8 39 9
HPV status negative 44 88 15 0.058 1.0 1.0
positive 8 37 4 0.43 (0.19 − 1.01) 0.29 (0.11 − 0.77)
- 0 3 0
AJCC stage (grouped) I & II 15 46 7 0.154 1.0
III & IV 33 57 7 1.78 (0.84 − 3.77)
- 4 25 5
Age group under 55 14 34 2 0.765 1.0
55−64 18 38 4 1.15 (0.47 − 2.82)
65−74 12 39 11 0.75 (0.30 − 1.88)
over 75 8 17 2 1.14 (0.37 − 3.51)
11q13 amp negative 28 85 13 0.021 1.0 1.0
positive 24 32 5 2.28 (1.15 − 4.51) 2.14 (1.02 − 4.48)
- 0 11 1
Tissue margin negative 44 104 17 1.0 1.0
positive 6 15 1 0.95 (0.34 − 2.62)
- 2 9 1
Nodal Involvement negative 12 54 7 0.005 1.0 1.0
positive 30 43 3 3.14 (1.43 − 6.87) 2.77 (1.06 − 7.22)
- 10 31 9
Extracapsular spread negative 11 23 2 0.488 1.0
positive 20 27 1 1.55 (0.62 − 3.85)
- 21 78 16
Perineural involvement negative 16 45 10 0.436 1.0
positive 21 42 2 1.41 (0.64 − 3.10)
- 15 41 7
Differentiation/Grade well 12 25 6 0.678 1.0
mod 28 69 8 0.85 (0.35 − 2.02)
poor 10 17 0 1.23 (0.42 − 3.62)
- 2 17 5
Tobacco use (smoking) Never 6 18 2 0.81
Ever 46 110 17
Alcohol use Never 4 24 5 0.072 1.0 1.0
Ever 48 104 14 2.77 (0.90 − 8.51) 2.14 (0.66 − 6.93)
Cumulative alcohol used None 4 24 5 0.027 1.0 1.0
<30 alc yrs 7 29 4 1.74 (0.46 − 6.63) 1.81 (0.46 − 7.12)
>30 alc yrs 39 65 9 3.60 (1.15 − 11.27) 2.43 (0.74 − 7.99)
- 2 10 1
Quit alcohol?e Never 4 24 5 0.042 1.0 1.0
Yes 8 24 2 2.00 (0.53 − 7.57) 1.40 (0.33 − 5.92)
No 36 60 9 3.66 (1.16 − 11.58) 2.85 (0.84 − 9.62)
- 4 21 3
Family history (cancer) No 28 55 8 0.192
Yes 24 73 11
a

In the dependent variable (cell line formation), a dashed line indicates cultures that were contaminated and subsequently lost from analysis.

b

P-values are from Fisher's exact test.

c

Odds ratios are adjusted for age (age group) and stage (grouped stage).

d

Cumulative use determined by multiplying the drink equivalent per day (1 shot = I beer = 1 glass wine) by years of alcohol use. Missing if quantity or duration was omitted on questionnaire.

e

Dependent upon patient reporting cessation of alcohol use prior to treatment for HNSCC and also providing a date of cessation.