Table 6.
Variables associated with formation of a cell line
Variable | Cell Linea | p-valueb | Unadjusted OR (95% CI) | Adjusted OR (95% CI)c | |||
---|---|---|---|---|---|---|---|
Y | N | - | |||||
199 | 52 | 128 | 19 | ||||
p53 status | WT | 35 | 74 | 8 | 0.637 | 1.0 | |
mut | 9 | 15 | 2 | 1.27 (0.50 − 3.19) | |||
- | 8 | 39 | 9 | ||||
HPV status | negative | 44 | 88 | 15 | 0.058 | 1.0 | 1.0 |
positive | 8 | 37 | 4 | 0.43 (0.19 − 1.01) | 0.29 (0.11 − 0.77) | ||
- | 0 | 3 | 0 | ||||
AJCC stage (grouped) | I & II | 15 | 46 | 7 | 0.154 | 1.0 | |
III & IV | 33 | 57 | 7 | 1.78 (0.84 − 3.77) | |||
- | 4 | 25 | 5 | ||||
Age group | under 55 | 14 | 34 | 2 | 0.765 | 1.0 | |
55−64 | 18 | 38 | 4 | 1.15 (0.47 − 2.82) | |||
65−74 | 12 | 39 | 11 | 0.75 (0.30 − 1.88) | |||
over 75 | 8 | 17 | 2 | 1.14 (0.37 − 3.51) | |||
11q13 amp | negative | 28 | 85 | 13 | 0.021 | 1.0 | 1.0 |
positive | 24 | 32 | 5 | 2.28 (1.15 − 4.51) | 2.14 (1.02 − 4.48) | ||
- | 0 | 11 | 1 | ||||
Tissue margin | negative | 44 | 104 | 17 | 1.0 | 1.0 | |
positive | 6 | 15 | 1 | 0.95 (0.34 − 2.62) | |||
- | 2 | 9 | 1 | ||||
Nodal Involvement | negative | 12 | 54 | 7 | 0.005 | 1.0 | 1.0 |
positive | 30 | 43 | 3 | 3.14 (1.43 − 6.87) | 2.77 (1.06 − 7.22) | ||
- | 10 | 31 | 9 | ||||
Extracapsular spread | negative | 11 | 23 | 2 | 0.488 | 1.0 | |
positive | 20 | 27 | 1 | 1.55 (0.62 − 3.85) | |||
- | 21 | 78 | 16 | ||||
Perineural involvement | negative | 16 | 45 | 10 | 0.436 | 1.0 | |
positive | 21 | 42 | 2 | 1.41 (0.64 − 3.10) | |||
- | 15 | 41 | 7 | ||||
Differentiation/Grade | well | 12 | 25 | 6 | 0.678 | 1.0 | |
mod | 28 | 69 | 8 | 0.85 (0.35 − 2.02) | |||
poor | 10 | 17 | 0 | 1.23 (0.42 − 3.62) | |||
- | 2 | 17 | 5 | ||||
Tobacco use (smoking) | Never | 6 | 18 | 2 | 0.81 | ||
Ever | 46 | 110 | 17 | ||||
Alcohol use | Never | 4 | 24 | 5 | 0.072 | 1.0 | 1.0 |
Ever | 48 | 104 | 14 | 2.77 (0.90 − 8.51) | 2.14 (0.66 − 6.93) | ||
Cumulative alcohol used | None | 4 | 24 | 5 | 0.027 | 1.0 | 1.0 |
<30 alc yrs | 7 | 29 | 4 | 1.74 (0.46 − 6.63) | 1.81 (0.46 − 7.12) | ||
>30 alc yrs | 39 | 65 | 9 | 3.60 (1.15 − 11.27) | 2.43 (0.74 − 7.99) | ||
- | 2 | 10 | 1 | ||||
Quit alcohol?e | Never | 4 | 24 | 5 | 0.042 | 1.0 | 1.0 |
Yes | 8 | 24 | 2 | 2.00 (0.53 − 7.57) | 1.40 (0.33 − 5.92) | ||
No | 36 | 60 | 9 | 3.66 (1.16 − 11.58) | 2.85 (0.84 − 9.62) | ||
- | 4 | 21 | 3 | ||||
Family history (cancer) | No | 28 | 55 | 8 | 0.192 | ||
Yes | 24 | 73 | 11 |
In the dependent variable (cell line formation), a dashed line indicates cultures that were contaminated and subsequently lost from analysis.
P-values are from Fisher's exact test.
Odds ratios are adjusted for age (age group) and stage (grouped stage).
Cumulative use determined by multiplying the drink equivalent per day (1 shot = I beer = 1 glass wine) by years of alcohol use. Missing if quantity or duration was omitted on questionnaire.
Dependent upon patient reporting cessation of alcohol use prior to treatment for HNSCC and also providing a date of cessation.