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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Nutrition. 2007 Feb 14;23(3):229–235. doi: 10.1016/j.nut.2006.12.006

TABLE 2.

Relationship of MTHFR with CIN 2 or 3 among 435 HR-HPV positive women

Genotype frequencies CIN1 2 or 3
CIN 2 or 3 n (%) CIN 1, ASCUS or normal cervical cytology n (%) OR adjusted for demographic and behavioral factors1 95% CI OR adjusted for demographic, behavioral and snutritional factors2 95% CI
MTHFR Ala/Ala 59 (74) 223 (63) Ref Ref
MTHFR Ala/Val 16 (20) 116 (33) 0.40 0.21–0.74 0.40 0.20–.80
MTHFR Val/Val 5 (6) 16 (4) 0.68 0.22–2.09 0.40 0.08–2.04
MTHFR Ala/Val or Val/Val 21 (26) 132 (37) 0.43 0.24–0.78 0.40 0.21–0.78
1

Multivariable adjustment for age, race, smoking (ever/never), age at first intercourse, use of hormonal contraception (yes/no), and study arm.-

2

Multivariable adjustment for age, race, smoking (ever/never), age at first intercourse, use of hormonal contraception (yes/no), study arm, and micronutrient concentrations of plasma folate, vitamins B-12, C, A, E, total carotene and riboflavin status.