Table 1.
Minimal inhibitory concentrations of RWJ-49815 and analogs against Gram-positive bacteria
| Minimal inhibitory concentrations,* μg/ml
| ||||
|---|---|---|---|---|
| Test organism | RWJ-49815† | RWJ-49619 | RWJ-49640 | RWJ-60953 |
| S. aureus ATTC 29213 | 1 | 4 | 4 | 16 |
| S. aureus ATTC 6538 | 2 | 2 | 1 | >32 |
| S. aureus OC667 (MR) | 2 | 2 | 2 | >32 |
| S. aureus OC2089 (MR) | 2 | 2 | 1 | >32 |
| S. epidermidis OC2603 | 2 | 2 | 2 | >32 |
| E. faecalis ATCC 29212 | 2 | 4 | 8 | >32 |
| E. faecalis OC3041 | 2 | 4 | 8 | >32 |
| E. faecium OC3312 (VanR) | 1 | 4 | 8 | >32 |
| S. pneumoniae OC3570 (PenS) | 2 | 16 | 8 | >32 |
| S. pneumoniae OC3561 (PenI) | 2 | 8 | 4 | >32 |
| S. pneumoniae OC3035 (PenR) | 1 | 8 | 4 | >32 |
*
Stock solutions of the compounds were prepared in dimethyl sulfoxide at 2.56 mg/ml and MICs were determined with the broth micro-dilution method as described by the National Committee for Clinical Laboratory Standards (1994) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically.
†
Molecular weights of compounds: RWJ-49815, 449; RWJ-49619, 407; RWJ-49640, 373; RWJ-60953, 466. MR, methicillin-resistant; VanR, vancomycin-resistant; PenS, penicillin-sensitive; PenI, intermediate penicillin-resistant; PenR, penicillin-resistant.