Table 2.

Resistance emergence of methicillin-resistant S. aureus strains to RWJ-49815 and ciprofloxacin

	RWJ-49815		Ciprofloxacin
S. aureus strain	MIC initial, μg/ml	Increase in MIC after passage (fold)	MIC initial, μg/ml	Increase in MIC after passage (fold)
OC667	4	2	0.5	4
OC2080	0.5	8	0.5	8
OC2083	2	2	0.5	4
OC2843	2	2	0.5	32
OC2878	0.5	8	0.25	32
OC2882	4	2	0.5	64
OC2997	4	2	0.5	32
OC2891	4	2	0.5	32
OC2898	0.5	4	0.25	64
OC2900	0.5	4	0.25	8

MIC, minimal inhibitory concentration.