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In vivo tumorigenic capacity of NGF-treated SCLC cells
| Mice with tumors | |
|---|---|
| Untreated SCLC cells | 7/7 |
| NGF-treated SCLC cells | 0/8 |
Female athymic Nu/Nu mice were xenografted in the dorsal region with either 107 NCI-N-592 cells or 107 NCI-N-592 cells previously exposed to 50 ng/ml NGF for 15 days. Tumor volume in mice receiving untreated cells was calculated by determining perpendicular diameters with callipers. Experiment was terminated 2 months after cell injection.
