(Left) Alignment of mouse sFRP amino acid sequences. The alignment includes the CRD of Drosophila frizzled (3), indicated by fz(CRD). The sFRP-4 sequence is incomplete; it is derived from a segment of genomic DNA that encompasses a single exon of the sFRP-4 gene. (Right) Dendrogram of CRD sequences in which the length of each horizontal line is proportional to the degree of amino acid sequence divergence. The region used to construct the dendrogram extends from the 1st to the 10th cysteine of the CRD. smo, smoothened; coll XVIII, collagen XVIII. Species origins are indicated by an uppercase letter: C, C. elegans; D, Drosophila; H, human; M, mouse; R, rat.