Figure 4.

Partial chromosome linkage maps showing the locations of the sFRP-1, sFRP-2, sFRP-3, and sFRP-4 genes in the mouse. The genes were mapped by interspecific backcross analysis. To the left of each chromosome map, the number of recombinant N2 animals divided by the total number of N2 animals typed for each pair of loci is presented. The recombination frequencies, expressed as genetic distance in centimorgans (± one standard error) are also shown. The upper 95% confidence limit of the recombination distance is given in parentheses when no recombinants were found between loci. Gene order was determined by minimizing the number of recombination events required to explain the allele distribution patterns. The positions of loci on human chromosomes, where known, are shown to the right of the chromosome maps. References for the map positions of most human loci can be obtained from the Genome Data Base, a computerized database of human linkage information maintained by The William H. Welch Medical Library of The Johns Hopkins University (Baltimore, MD).