Figure 6.
Migration, invasion, and dissemination of the SDF(K1R)-KDEL clones. Shown are the results of two of five clones, SDF(K1R)-K10 and SDF(K1R)-K30. (a) Data are the percentage of cells that have migrated in 2 hours through a filter to the lower chamber of a transwell containing different concentrations of SDF-1 and are averages of five experiments performed. (b) Data are the percentages of cells that have invaded into the REF monolayer after 1 hour and are averages ± SEM of six experiments performed. (c) Survival of syngeneic AKR mice injected intravenously with 5 × 105 cells is shown. Animals were killed when moribund or after 100 days.