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Renal changes in the early stage. (a) Kidney weight/body weight ratio. Inset: Sagittal section of the kidney at 4 months of age. Bar, 5 mm. (b) Albuminuria. Filled circles, DM+RAGETg+; open circles, DM+RAGETg–; filled squares, DM–RAGETg+; open squares, DM–RAGETg–. Data are mean ± SEM. *P < 0.02, †P < 0.05 compared with DM+RAGETg–. Statistical analysis was performed by t test.
