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. Author manuscript; available in PMC: 2008 Jul 20.
Published in final edited form as: Biochem Biophys Res Commun. 2007 May 22;359(1):94–101. doi: 10.1016/j.bbrc.2007.05.072

Fig. 1.

Fig. 1

Comparison of two types of “structure-switching signaling aptamer”. Ligand binding to a beacon aptamer disrupts an intramolecular duplex. Signaling through the duplex-to-complex structure-switching mechanism requires disruption of an intermolecular duplex. In both strategies, structure-switching separates a fluorophore from a quencher resulting in increased fluorescence intensity.