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. 2007 Nov-Dec;13(11-12):605–614. doi: 10.2119/2007-00071.Rohrbach

Figure 4.

Figure 4

IL-6 induction in human heart failure. Left ventricular IL-6 mRNA (A) was determined by RT-PCR, IL-6 protein (B) was determined by Western Blotting, and AP-1, CREB, and NF-κB activation (C) were examined using TransAM assays in nonfailing donor hearts and in explanted hearts from patients with DCM or with ICM. β+: patients treated with β-blockers prior to explantation; β−: patients treated without β-blockers. Significance of differences: *P < 0.05; **P < 0.01; ***P < 0.001, as indicated. Note that the significant differences shown under the figures describe the comparison between donor hearts, failing hearts from patients receiving β-blocker treatment (DCM + ICM), or failing hearts from patients without β-blocker treatment (DCM + ICM) respectively.