Table 1.

A Classification of Iron Storage Disease

Hereditary

Autosomal Dominant Ferroportin Deficiency African Iron Overload (?)

Autosomal Recessive Hereditary Hemochromatosis due to HFE mutations Hereditary Hemochromatosis due to transferrin receptor 2 mutations Juvenile Hemochromatosis due to hepcidin mutations Juvenile Hemochromatosis due to hemojuvelin mutations Iron Overload secondary to atransferrinemia Iron Overload secondary to aceruloplasminemia

Acquired Thalassemia Myelodysplastic Syndromes Congenital Dyserythropoietic Anemias Sickle Cell Disease and other Hemoglobinopathies Red Cell Enzyme Deficiencies Multiple Blood Transfusions