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Structural comparison of DHPI with insulin and insulin analogs. (a) Main chain superposition of B-chains of DHPI molecule 1 (boldface lines) and 2Zn insulin, DPI, DHI, and des (B1–B2) despentapeptide (B26–B30) insulin (regular lines). Only B9–B19 were used to calculate the superposition matrices. (b) Similar comparison of DHPI molecule 1 (boldface lines) and molecule 2 (regular lines). Residues are labeled as in Fig. 1. [This figure was drawn with the program frodo (27).]
