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Intranuclear localization of Ro RNA in a cultured keratinocyte by in situ hybridization with hY1 + hY3 + hY4 + hY5 probe mixture. A cluster of gold particles (10 nm) is present within the nucleoplasm. Glutaraldehyde fixation was 1.6%. Image produced by uranyl acetate staining. (Bar = 0.5 μm.)
