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. Author manuscript; available in PMC: 2008 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2007 May 22;88(2):217–224. doi: 10.1016/j.nlm.2007.03.010

Figure 2.

Figure 2

The hippocampus, posterior cortex and cerebellum of Tg2576 mice have measurable Aβ1–42 and display increased CaN activity, which is reversed by treatment with FK506. a) CaN (PP-2B) enzymatic activity assay and b) human Aβ1–42 ELISA in the hippocampus (HIPP), posterior cortex (PCTX) and cerebellum (CB) of 5 month old Tg2576 mice treated with FK506 (10 mg/kg ip) 6 hr before sacrifice. Bars represent the average ± S.D. of five animals per group. *p<0.001 vs. vehicle-treated wild type (WT) mice (two-tailed Student’s t test with Bonferroni correction for multiple comparison). n.d.: none detected (below the ELISA detection limit).