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Outline of TOR/FRAP pathways. Extracellular signals pass through the Tor and FRAP proteins, suppressing quiescence or meiosis and promoting cell cycle progression. The pathway can also be activated with cell-permeable RNA ligands that inhibit protein synthesis, a process reminiscent of the activation of the Mec1p-mediated pathway by cell-permeable DNA ligands or by inhibitors of DNA synthesis (2).
