(A) Alignment of homeodomain sequences for the paired-type homeodomain-containing proteins. Only amino acid residues that differ from those of the Rax homeodomain are shown. (B) Sequence alignment of OAR domain sequences. Conserved identical amino acid residues are shown with a dark shadow. Conservative changes of amino acid residues are shown with a light shadow. Sequences of homeodomains and OAR domains are taken from the following references: aristaless (33), chx10 (20), pax3 (35), pax6 (10), pax7 (36), alx3 (37), phox2 (38), s8 (39), cart1 (40), rk2 (41), paired (34), and otp (42).