. 1997 Apr 1;94(7):3094–3099. doi: 10.1073/pnas.94.7.3094

Table 3.

Putative HFH-4 target genes

Gene	GenBank accession no.	Promoter position	Promoter sequence	HFH-4 binding^*
Choroid plexus epithelium
Human prothrombin	LEFT M17262	−2013/−2025	TTTTGTTTGTTTt	+++
Human βAPP	LEFT M24546	−568/−580	TTTTGTTTGTTTt	+++
Rat α2-macroglobulin	LEFT M23567	−2016/−2004	ATTTGTTTGTTTg	++
Human α1AC	LEFT X94997	−1227/−1215	gTTTGTTTGTTTt	+++
Mouse IGF-II	LEFT M36329	−701/−713	CAATGTTTGTTct	+
Rat growth horm. Rec.^†	LEFT S76627	−136/−148	TTTTGTTGTTgTt	+++
Bronchiolar epithelium
Human CFTR^†^‡	LEFT M58478	−1739/−1751	ATcTGTTGTTTgG	+
Rat HNF-3α	LEFT U86584	−465/−477	CTTTGTTTacaaA	++
Rat CCSP	LEFT X51318	−1728/−1716	TTTTGTTTGTTTg	++
Mouse CCSP	LEFT L24372	−2072/−2060	TTTTGTTTGTTTg	++
Rat HNF-3β	LEFT U50407	−97/−85	CccTGTTTGTTTT	—
HFH-4 consensus:			HWDTGTTTGTTTA

βAPP, β amyloid precursor protein; α1AC, antichymotrypsin; IGF-II, insulin-like growth factor-II; horm. rec., hormone receptor; CFTR, cystic fibrosis transmembrane conductance regulator; and CCSP, clara cell secretory protein genes.

HFH-4 protein binding affinity is as follows: +++, high; ++, moderate; +, weak; −, none.

^†

Homology with the HFH-2 no. 7 sequence (Table 2), which binds HFH-4 protein with high affinity.

^‡

CFTR is expressed in bronchiolar and choroid plexus epithelium. Nucleotides which deviate from the HFH-4 consensus or HFH-2 no. 7 sequence are indicated in lowercase letters.