Figure 4.

Alignment of wild-type XPG with those predicted in the three XP-G/CS patients and the two sibling non-CS XP-G patients. The number of amino acids in each protein is listed on the right. Hatched areas indicate: N and I, conserved regions; NLS, putative bipartite nuclear localization signal; C, basic domain. Mutations: 1, Single A deletion within nucleotides 2170–2172; 2, nonsense C → T transition at nucleotide 984; 3, single T deletion at position 2972 (black area indicates the frameshift between amino acids 926 and 980); 4, nonsense G → T transversion at nucleotide 3075; and 5, missense C → T transition at nucleotide 2572.