Figure 1.

Sequences of reporter gene mutations in Pms2 nullizygous mice. (A) Mutations in the supFG1 gene in 3340/Pms2 nullizygotes. Mutations from three different mice from independent litters are shown, with the tissues of origin indicated. Base substitutions are listed above the original sequence, and single-base pair deletions or insertions are indicated by Δ or +, respectively, above the corresponding site. Mononucleotide repeat sequences are highlighted by double underlining. CpG sequences, potential sites of cytosine methylation, are noted by a single underline. (B) Mutations in the supF gene in 1139/Pms2 nullizygotes and in wild-type 1139 mice, as indicated.