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. 1997 Apr 1;94(7):3145–3150. doi: 10.1073/pnas.94.7.3145

Figure 4.

Figure 4

Loss of yeast NC2 function compensates for the global defect in class II gene expression caused by the SRB4 mutant holoenzyme. (a) ncb1-1 mutation suppresses the growth defect of the srb4-138 mutant strain at the restrictive temperature. Growth of wild-type (Z579), srb4-138 (Z628), srb4-138 ncb1-1 (Z804), and ncb1-1 (Z805) strains in YPD medium at 30°C and after shifting to the restrictive temperature of 35.5°C. (b) The global decline in mRNA levels at the restrictive temperature in srb4-138 mutant strain is alleviated by the ncb1-1 mutation. (c) Global levels of mRNA are increased in the ncb1-1 strain relative to the wild-type strain. (d) The decrease in synthesis of individual class II messages at the restrictive temperature in the srb4-138 mutant strain is reversed by the ncb1-1 mutation.