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The bob1 mutation results in a Pro → Leu substitution at residue 83 of Mcm5p/Cdc46p. (A) bob1::URA3 dbf4-1 strains expressing wild-type Cdc46p, mutant cdc46-bob1p, or mutant/wild-type chimeras were tested for growth at 23°C and 37°C. +, Growth; −, no growth after 5 days on rich media. (B) Pro is conserved among Mcm2p, Mcm4p, and Mcm5p family members. The conserved residues are shown in boldface type.
