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Folding topology and mAb localization for the LFA-1 α subunit I domain (21) and predicted LFA-1 α subunit β-propeller domain (23). β-Strands are arrows, predicted disulfide bonds are horizontal lines, putative Ca2+ ions bound to 1-2 loops are filled circles, and boundaries between FG-GAP repeats are marked with vertical dashes. The regions are shown to which mAbs used in this study map, as determined with human × mouse αL subunit chimeras (19, 36) (see Materials and Methods).
