Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2008 Oct 15.

Published in final edited form as: Bioorg Med Chem. 2007 Jul 25;15(20):6565–6573. doi: 10.1016/j.bmc.2007.07.001

DQ2 dependent T cell stimulation of T cell line P28 TCL2 by dimeric peptides 8–15. (A) T cell stimulation caused by dimeric peptides 8–15 in the absence of antigen or by antigen peptide LQLQPFPQPELPYPQPELPY (Ag) at 50 μM or 10 μM. The background in the absence of blockers is 170 CPM. □ 50 μM dimeric peptide; 10 μM dimeric peptide or antigen. (B) Blocking compounds 8, 10, and 13 block T cell proliferation caused by 10 μM antigen peptide LQLQPFPQPELPYPQPELPY in a dose dependent fashion. □ 50 μM dimeric peptide, 10 μM antigen; 10 μM dimeric peptide, 10 μM antigen; ■ 0 μM dimeric peptide, 10 μM antigen;▤50 μM dimeric peptide, 0 μM antigen.

Inline graphic — DQ2 dependent T cell stimulation of T cell line P28 TCL2 by dimeric peptides 8–15. (A) T cell stimulation caused by dimeric peptides 8–15 in the absence of antigen or by antigen peptide LQLQPFPQPELPYPQPELPY (Ag) at 50 μM or 10 μM. The background in the absence of blockers is 170 CPM. □ 50 μM dimeric peptide; 10 μM dimeric peptide or antigen. (B) Blocking compounds 8, 10, and 13 block T cell proliferation caused by 10 μM antigen peptide LQLQPFPQPELPYPQPELPY in a dose dependent fashion. □ 50 μM dimeric peptide, 10 μM antigen; 10 μM dimeric peptide, 10 μM antigen; ■ 0 μM dimeric peptide, 10 μM antigen;▤50 μM dimeric peptide, 0 μM antigen.