TABLE 2.
Measurement of erectile function (ICP/BP) in old rats (9–10 months) after intracorporal injection of pVAX, pVAX-hSlo, or pVAX-Vcsa1
Mean (sd) ICP/BP
|
||||
---|---|---|---|---|
Treatment (dose, μg) | N | Basal | CN stimulation 0.75 mA | CN stimulation 4 mA |
pVAX (100) | 8 | 0.063 (0.020) | 0.22 (0.12) | 0.33 (0.18) |
pVAX-hSlo (100) | 6 | 0.085 (0.030) | 0.69 (0.033)* | 0.75 (0.06)* |
pVAX-Vcsa1 (80) | 4 | 0.148 (0.071)* | 0.35 (0.21)* | 0.41 (0.18)* |
pVAX-Vcsa1 (25) | 3 | 0.097 (0.029) | 0.54 (0.21)* | 0.62 (0.13)* |
pVAX-Vcsa1 (5) | 3 | 0.073 (0.023) | 0.43 (0.11)* | 0.64 (0.046)* |
The rats weighed >500 g.
P < 0.5 vs control rats (pVAX), one-way anova.