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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Cell Signal. 2007 Jun 22;19(11):2218–2226. doi: 10.1016/j.cellsig.2007.06.006

Figure 2. Domain architecture of ASF/SF2.

Figure 2

Domain structure of the prototypical SR protein ASF/SF2 is shown. The two RNA recognition motifs are designated RRM1 and RRM2. A docking motif (D) for binding to SRPK1 is located between residues 184-197. The two serine-rich regions of the RS domain (RS1 and RS2) are indicated; individual phosphorylation sites are represented by black bars. SRPK1 phosphorylates serines in RS1, while Clk/Sty phosphorylates both RS1 and RS2.