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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Cell Signal. 2007 Jun 22;19(11):2218–2226. doi: 10.1016/j.cellsig.2007.06.006

Figure 4. Domain structure of p130Cas.

Figure 4

Cas contains an SH3 domain (SH3), proline-rich sequences (Pro), a substrate region containing 15 YXXP repeats, a serine-rich region (Ser), and a C-terminal Src binding site. The Src binding site contains a Pro-rich sequence that binds to the SH3 domain of Src, and a phosphorylated Tyr (Y668) that binds to the SH2 domain of Src. The positions of the four YQXP motifs and nine YDXP motifs are indicated.