Table 2.
Plasma metabolite, hormone, and cytokine data from high-fat-fed WT and Acc2−/− mice
| Parameter | Fast |
Clamp |
Fed |
|||
|---|---|---|---|---|---|---|
| WT (n = 9) | Acc2−/− (n = 9) | WT (n = 9) | Acc2−/− (n = 9) | WT (n = 8) | Acc2−/− (n = 6) | |
| Glucose, mg/dl | 131 ± 8 | 96 ± 8* | 118 ± 2 | 124 ± 3 | 214 ± 6 | 189 ± 12 |
| Insulin, microunits/ml | 16.6 ± 1.2 | 11.7 ± 1.0* | 77.9 ± 3.3 | 57.4 ± 6.4† | ND | ND |
| Fatty acids, mEq/liter | 1.05 ± 0.11 | 1.15 ± 0.05 | 0.74 ± 0.08 | 0.43 ± 0.06* | 0.45 ± 0.04 | 0.46 ± 0.05 |
| Triglycerides, mg/dl | 115 ± 15 | 113 ± 8 | ND | ND | 107 ± 18 | 99 ± 5 |
| Cholesterol, mg/dl | 100 ± 10 | 109 ± 7 | ND | ND | 116 ± 13 | 105 ± 13 |
| β -Hydroxybutyrate, mM | 1.76 ± 0.13 | 2.83 ± 0.35* | ND | ND | 0.26 ± 0.03 | 0.48 ± 0.11† |
| Resistin, pM | 1,607 ± 333 | 1,498 ± 172 | ||||
| TNF-α, pM | 2.31 ± 0.25 | 3.19 ± 0.67 | ||||
| IL-6, pM | 4.75 ± 0.81 | 6.25 ± 1.86 | ||||
| Leptin, pM | 3,499 ± 1,627 | 2,869 ± 981 | ||||
| Adiponectin, μg/ml | 7.5 ± 1.6 | 9.3 ± 1.8 | ||||
*, P < 0.01; †, P < 0.05 (Acc2−/− vs. WT); ND, not determined.