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Model of genome-wide antisilencing mediated redundantly by H2A.Z and Set1. In wild-type cells, nucleosomes containing H2A.Z (blue) and methylated on H3-K4 (green) by Set1 antagonize the binding of the Sir2–4 complex (red) across euchromatin. Disruption of both these antisilencing pathways in set1Δ htz1Δ cells results in redistribution of Sir proteins from telomeric heterochromatin to ectopic sites across the genome.
