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. 2007 Oct 9;104(42):16685–16689. doi: 10.1073/pnas.0707842104

Fig. 1.

Fig. 1.

C2-8 has brain bioavailability at nontoxic doses. (A) Gradient chromatography coupled with 16-channel colorimetric array detection enabled the detection of C2-8 in mouse brain. (Left) Chromatogram showing C2-8 standard (0.8 μg/ml). The peaks were detected in channels 12–15 at ≈90-min retention time. The analytical values were determined from total integrated values of peaks from channel 12–15. (Right) Chromatogram shows brain levels of C2-8 in wild-type mice receiving 50 mg/kg C2-8 p.o. for 5 days. Five hours after the last dose, levels of C2-8 were determined in cortex based on comparison with standards and found to be 25 μM. (B) Brain and plasma levels of C2-8 in wild-type mice after single p.o. administration of 5 (filled circle), 10 (open circle), 25 (filled triangle), and 50 (open triangle) mg/kg C2-8. Levels were determined 1, 4, and 8 h after dosing. n = 5. Error bars represent SD.