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. 2007 Oct 9;104(42):16685–16689. doi: 10.1073/pnas.0707842104

Fig. 3.

Fig. 3.

C2-8 increases striatal neuronal cell body volume in R6/2 mice. (A and B) C2-8 treatment has no effect on brain weight and striatal volume in R6/2 mice. (C) Thionin-stained sections of neostriatum from a wild-type littermate mouse (Right), a placebo-treated R6/2 mouse (Center), and a C2-8-treated R6/2 mouse (Left) at 13 weeks of age. There is evidence of neuronal atrophy in the untreated R6/2 mouse with relative preservation of neuronal atrophy in the C2-8-treated mouse. (Scale bars, 25 μm.) (D) Stereological quantification of striatal neuronal cell body volume. Neuronal volume is significantly reduced in R6/2 mice as compared with wild-type littermates. C2-8 treatment partially rescues the loss of striatal neuronal cell body volume in a dose-dependent manner. Error bars represent SEM, n = 10; *, P < 0.05.