Fig. 4.

C2-8 decreases size of neuronal intranuclear huntingtin aggregates. (A) Immunodetection of intraneuronal huntingtin aggregates by using EM48 antibody in the neostriatum of 13-week-old R6/2 mice with and without C2-8 treatment. (Scale bars, 25 μm.) (B) Stereological counts of striatal intraneuronal aggregates in R6/2 mice. C2-8 treatment had no effect on aggregate density. (C) C2-8 treatment significantly reduced the striatal nuclear aggregate volume in R6/2 mice. Error bars indicate SEM, n = 10; ***, P < 0.001.