Table 2.
Treatment | % Inhibition of binding | |
---|---|---|
Cerebellum | Hippocampus | |
Ethanol (5–50 mM) | < 5.0 | <5.0 |
Ethanol (200 mM) | 7.8 ± 0.8 | 10.5 ± 1.7 |
Ethanol (500 mM) | 12.4 ± 0.9 | 13.9 ± 2.1 |
[3H]muscimol (15 nM) binding to the solubilized GABAA receptors from the rat cerebellum and hippocampus was found to be 0.12 ± 0.01 pmol/mg protein (n=3) and 0.09 ± 0.01 pmol/mg protein (n=3), respectively.