Table 2.
Data for GA-DZ conjugates against human tumor cell replication
| Cmpd | ED50 (μM) / Cell linea | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| KB | KB-VIN | A549 | 1A9 | HCT-8 | ZR-751 | PC-3 | DU-145 | LN-Cap | |
| 5 | 1.6 | 2.5 | 2.0 | 0.9 | 1.7 | 2.8 | 1.4 | 3.1 | 0.6 |
| 29 | 0.8 | 2.8 | 2.2 | 0.8 | 1.9 | 3.0 | 1.1 | 3.6 | 2.8 |
| 30 | 0.9 | 1.9 | 2.8 | 1.6 | 2.0 | 1.9 | 2.8 | 9.9 | 6.5 |
| 31 | 6.2 | >15 | 15.5 | 5.9 | 2.6 | >15 | 7.4 | >15 | 1.9 |
| 32 | 1.8 | 1.7 | 1.7 | 1.1 | 2.7 | 5.2 | 3.3 | 5.8 | 1.1 |
| 33 | 2.9 | 13.2 | 3.0 | 1.8 | 4.9 | 8.8 | 3.5 | >15 | 6.8 |
| 34 | 3.0 | 8.7 | 3.2 | 1.3 | 2.2 | 2.7 | 1.6 | 2.7 | 4.4 |
| 35 | NA | NA | >14 | >14 | >14 | NA | >14 | >14 | >14 |
| 36 | 9.9 | NA | >14 | 13.3 | >14 | >14 | 14.1 | >14 | 14.1 |
| 37 | NA | NA | NA | >14 | >14 | NA | 14.1 | >14 | 14.1 |
| 38 | >14 | >14 | NA | NA | >14 | NA | >14 | 13.0 | >14 |
| GA | >21 | >21 | NA | >21 | 19.5 | NA | >21 | >21 | >21 |
| DZ | NA | NA | >52 | 33.9 | >52 | >52 | >52 | >52 | 51.0 |
| DOXb | 0.1 | 4.97 | 0.18 | 0.02 | 1.20 | 0.04 | 0.26 | 0.15 | 0.04 |
a
Human epidermoid carcinoma of the lung (A549), ovarian (1A9), colon (HCT-8), breast (ZR-751), prostate (PC-3, DU-145, LN-Cap).
b
Doxorubicin