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. Author manuscript; available in PMC: 2007 Oct 17.
Published in final edited form as: Neuron. 2007 Jul 19;55(2):217–230. doi: 10.1016/j.neuron.2007.06.029

Figure 5. Lack of YY1 does not affect the ability of oligodendrocyte progenitors to exit from the cell cycle.

Figure 5

(A) Confocal image of spinal cord sections of p2 yy1 cko and control siblings (ctrl) in vivo labeled with BrdU for 1 hour. Immunohistochemistry with YY1 (red), BrdU (green) and DAPI (blue) revealed a similar distribution BrdU+ cells in mice of the two genotypes. Scale bar = 20μm. (B) Quantification of BrdU+ cells in white matter tracts of the spinal cord at the indicated time points; *p<0.05. (C) Representative images of spinal cord sections of control and cko mice stained with antibodies against Ki-67 (green) to identify cells in any phase of the cell cycle except for G0 and BrdU (red) to identify cells in S phase at the time of labeling. (D) Cell cycle exit index was calculated by dividing the number of BrdU+/Ki-67− cells, by the total number of BrdU+ cells. Scale bar = 20μm.