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. Author manuscript; available in PMC: 2007 Oct 17.
Published in final edited form as: Neuron. 2007 Jul 19;55(2):217–230. doi: 10.1016/j.neuron.2007.06.029

Figure 6. YY1 is a repressor of oligodendrocyte differentiation inhibitors Id4 and Tcf4.

Figure 6

(A) Validation of gene expression profiling studies in the cortex of yy1 cko mice and control littermates at p2, by semi-quantitative (A) and quantitative (B) RT-PCR. The RNA levels were normalized to the levels of GAPDH and the values in the control mice were arbitrarily set as 1. *p<0.05. (C) The expression level of Tcf4 and Id4 was down-regulated in oligodendrocyte progenitors transfected with pCX-yy1-EGFP (YY1) and not in cells transfected with pCX-EGFP vector as control. (D) Luciferase activity of immortalized oligodendrocyte progenitors (Oli-neu cells) co-transfected with Tcf4, and either myelin (MBP-luc, CGT-luc) or astrocytes-specific (GFAP-luc) promoters driving luciferase reporters. The luciferase activity in pCDNA3 transfected controls was arbitrarily set as 100; ** p<0.01.