Table 1.
Amino acid sequences of the A8Q3L4 family of peptides used in this study, including computed hydrophobic moments and partitioning free energies.
Amino Acid Sequence | Name | Hydrophobic a moment (μH) | bΔGWW (kcal mol−1) |
---|---|---|---|
AC-LQALAAQALQAAALA-GW-NH2 | A8Q3L4-0.55 | 0.55 | −3.53 |
Ac-LAQAAALQLLAAQAA-GW-NH2 | A8Q3L4-2.00 | 2.00 | −3.53 |
Ac-AQLAALAALQAAQLA-GW-NH2 | A8Q3L4-2.86 | 2.86 | −3.53 |
Ac-AAAQAAAQLLQALLA-GW-NH2 | A8Q3L4-4.72 | 4.72 | −3.53 |
Ac-QLAQALAAALAALAQ-GW-NH2 | A8Q3L4-5.51 | 5.51 | −3.53 |
Ac-QALQALAAALAALAQ-GW-NH2 | A8Q3L4-5.54 | 5.54 | −3.53 |
Hydrophobic moments were computed using the Totalizer module of MPEx, available over the World Wide Web: http://blanco.biomol.uci.edu/mpex
Free energies of transfer from water to bilayer interface based upon the Wimley-White17 experiment-based interfacial hydrophobicity scale. These were also computed using the Totalizer module of MPEx (above).