Fig 1.
Effect of an 8-week treatment with AII blockers on the progression of azotemia (as BUN) induced by an 18.8 Gy radiation dose. Rats were given TBI in 6 fractions followed by a syngeneic BMT. Some animals received no further treatment (●), and others were treated from 4–12 weeks after irradiation with an AT1 blocker (L-158,809) at 2 mg/kg/day (△), with an AT2 blocker (PD-123319) at 15 mg/kg/day (○) or with a combination of the AT1 blocker and the AT2 blocker (●). Data is shown as medians with 20–80% ranges. Values for age-matched controls are shown by the hatched area.