Table 3.

Conformational adaptation energies (kcal/mol)

	Single Trajectory		Separate Trajectory		Adaptation Energy
Free U1A (CLOSED)		σa		σa
Wild Type	−4216.39	2.30	−4200.80	2.09	−15.59
F56A	−4206.42	2.37	−4188.34	2.89	−18.08
F56L	−4238.23	2.45	−4209.61	2.28	−28.62
F56W	−4211.28	2.23	−4197.67	2.54	−13.61
Free U1A (OPEN)
Wild Type	−4216.39	2.30	−4235.34	2.24	18.95
F56A	−4206.42	2.37	−4228.46	2.09	22.04
F56L	−4238.23	2.45	−4261.49	2.05	23.26
F56W	−4211.28	2.23	−4233.51	2.08	22.23
Free SL2 RNA
Wild Type	−4608.26	1.47	−4628.29	0.58	20.03
F56A	−4603.79	1.68	−4628.29	0.58	24.50
F56L	−4599.49	1.46	−4628.29	0.58	28.80
F56W	−4601.03	1.44	−4628.29	0.58	27.26

^aStandard error of mean values.