Figure 5. Effect of buffer parameters on calcium dynamics.

A–C. Parameter space analysis similar as in Figure 3 and 4 for model parameters K_D,endo (dissociation constant for endogenous buffer) and B_tot,endo (total concentration endogenous buffer). Plus signs indicate default parameter values for spines (red) and dendrites (blue) as listed in Table 2. C. Overlay of contour plots of rise times and decay times show areas of overlap where the model fits the experimental rise and decay times, with different ranges of B_tot,endo for spines (transparent red bar) and dendrites (transparent blue bar). D–F Similar analysis for model parameters k_on,endo (binding rate of the endogenous buffer) and k_{off, endo} (unbinding rate of the endogenous buffer). F. Parameter ranges for k_on,endo and k_{off, endo} in spines and dendrites display a large overlap.