Table 3.

Cytotoxic Activity of Compounds 1, 2, 4, and 5^a

	Cell lineb
Compound	Lu1	LNCaP	MCF-7
1c	0.0012	0.0015	0.0015
2	1.8	1.4	1.8
4	17.5	21.0	16.1
5	18.1	16.0	13.5
Paclitaxeld	0.0023	0.0047	0.0007

^aCompounds 3, 3a, 4a, 6 - 8 were considered to be inactive, since their ED₅₀ values were >20 μM against the tested cell lines. Results are expressed as ED₅₀ values (μM)

^bKey to cell lines used: Lu1 = human lung cancer; LNCaP = hormone-dependent human prostate cancer; MCF-7 = human breast cancer.

^cData obtained from ref. 8.

^dUsed as a positive control.