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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Radiother Oncol. 2007 Jun 27;84(1):75–83. doi: 10.1016/j.radonc.2007.05.025

Table 1.

Relationship between occurrence of wound healing complications (WHC) and micronuclei (MN) and binucleation index (BNI) in fibroblasts in situ used for culturing and in cultured fibroblasts

No WHC N WHC N
MN Burden in in situ fibroblasts used for culturing 99 (22 - 452) 17 93 (44 - 196) 6
1Induced MN response in confluent cultures (Gy10) 0.9 (0.6 - 2.8) 14 0.7 (0.3 - 1.9) 7
2Induced BNI response in confluent cultures (%) 84 (65 - 91) 15 84 (79 - 90) 5
1Induced MN response in non-confluent cultures (Gy10) 0.9 (0.6 - 2.6) 15 1.0 (0.7 - 1.3) 2
2Induced BNI response in non-confluent cultures (%) 59 (31 - 84) 17 65 (47 - 81) 6

Medians are shown (range in brackets).

1

Induced MN response is expressed as equivalent single dose (α/β=10, Gy10) required to induce 150 MN per 1000 BN cells for cultured fibroblasts.

2

Induced BNI response is expressed as per cent decrease in BNI at 1 Gy in non-confluent cultures and as per cent decrease in BNI at 2.4 Gy in confluent cultures.