Table 4.

Multivariate Models for Macrolide, Penicillin, and Cephalosporin (Ceftriaxone and Cefotaxime) Non-susceptibility

	Model for Macrolide Non-Susceptibility OR (95% CI)	Model for Penicillin Non-Susceptibility OR (95% CI)	Model for Cephalosporin Non-Susceptibility OR (95% CI)
Age (per 10 years ↑)	1.0 (0.92, 1.07)	1.0 (0.92, 1.03)	1.0 (0.90, 1.06)
Male	0.8 (0.6, 1.1)	0.8 (0.6, 1.1)	1.1 (0.7, 1.6)
White	1.3 (0.9, 1.9)	1.2 (0.9, 1.5)	1.0 (0.6,1.5)
Region
Northeast	Reference	Reference	Reference
Midwest	0.9 (0.6, 1.5)	0.8 (0.6, 1.2)	0.8 (0.5, 1.4)
South	1.7 (1.1, 2.8)*	1.9 (1.4, 2.7) *	1.6 (0.9, 2.6)
West	1.2 (0.6, 2.2)	0.9 (0.6, 1.3)	0.3 (0.1, 0.7) *
Medicaid insurance	1.0 (0.7, 1.6)	1.0 (0.7, 1.3)	0.6 (0.3, 0.96) *
Evidence of prior antibiotic drug therapy	4.0 (2.1, 7.3)*	3.3 (2.1, 5.1) *	2.0 (1.04, 3.8) *
Immunosuppressed patient	1.5 (1.0, 2.2)	1.5 (1.1, 2.0) *	1.3 (0.8, 2.1)
Admitted over night in past month	1.5 (0.9, 2.5)	1.5 (1.01, 2.3)*	2.6 (1.5, 4.5) *
Focal infection	0.9 (0.6, 1.4)	0.9 (0.7,1.3)	0.7 (0.4, 1.1)
Antibiotic allergy	1.7 (1.1, 2.6)*	1.3 (0.9, 1.8)	1.4 (0.9, 2.3)

Macrolide Model

Of n=893 in model, n=159 had intermediate/resistant test results.

Area under the ROC curve: 0.67, Hosmer-Lemeshow goodness of fit p-value: 0.56

Penicillin Model

Of n=1412 in model, n=350 with intermediate/resistant test results.

Area under the ROC curve: 0.65, Hosmer-Lemeshow p-value: 0.57

Cephalosporin Model

Of n=1210 in model, n=111 with intermediate/resistant test results.

Area under the ROC curve: 0.69, Hosmer-Lemeshow p-value: 0.49

^*Confidence intervals that do not cross 1 are statistically significant