TABLE 1.

Between-subject variance (CV = coefficient of variation) of individual noncompartmental and compartmental parameters and their correlation (r = correlation coefficient) with the known density of the SERT

	Uncorrected		Corrected
Parameter	CV	r	CV	r
Tissue radioactivity at T = 85 minutes
A85	33.83	0.541	44.45	0.661
Impulse response function (noncompartmental)
fmax	20.27	− 0.179
fT	25.93	0.511	34.69	0.623
frel	18.69	0.787	36.45	0.814
Two-parameter model (compartmental)
K1,2par	16.74	− 0.343
k2,2par	55.75	− 0.789
Three-parameter model (compartmental)
BV3par	30.50	− 0.391
K1,3par	17.92	− 0.336
k2,3par	57.31	− 0.769
Four-parameter model (compartmental)
K1,4par	23.93	− 0.130
k2,4par	52.37	0.212
k3,4par	62.80	0.111
k4,4par	137.18	− 0.436
Five-parameter model (compartmental)
BV5par	42.75	−0.106
K1,5par	23.75	−0.196
k2,5par	54.78	0.116
k3,5par	66.56	0.254
k4,5par	135.67	0.061
Distribution volumes
DVt,2par	79.04	0.622	90.71	0.622
DVt,3par	79.08	0.322	91.03	0.322
DVt,4par	125.32	0.308	141.87	0.308
DVt,5par	101.91	0.368	112.14	0.395
DVs,4par	133.77	0.308
DVs,5par	111.43	0.395
lnDVt,2par	16.70	0.715	22.29	0.742
lnDVt,3par	16.85	0.652	22.61	0.694
lnDVt,4par	22.42	0.796	32.24	0.816
lnDVt,5par	21.02	0.696	26.58	0.730
lnDVs,4par	28.60	0.800
lnDVs,5par	25.58	0.673

Uncorrected parameters represent those derived from [¹¹C](+)McN5652 while corrected parameters represent those corrected for nonspecific binding by subtraction of the identical parameter obtained with [¹¹C](−)McN5652. A₈₅, Activity (nCi/cc/mCi injected dose) measured with PET 75–95 minutes post injection; f_max, maximum value of the impulse response function; f_T, value of the impulse response function at T = 75 minutes post injection; f_rel, f_T/f_max; k₁, compartmental uptake; k₂, compartmental washout; BV, blood volume; 2par, 2 parameter model; DV, total apparent tissue distribution volume; DV_S, apparent distribution volume of specific binding.