Table 2.
Rates of specific classes of frameshift mutations under low-transcription conditions
| Allele
Information |
pLYS-lys2ΔA746 (Endoa) |
pLYS-lys2ΔA746 SAME |
pLYS-lys2ΔA746 OPPOSITE |
pTET-lys2ΔA746 SAME |
pTET-lys2ΔA746 OPPOSITE |
|---|---|---|---|---|---|
| Total | 14
(0 – 16) |
6.8
(4.9 – 7.7) |
9.4
(8.4 – 12.4) |
14.4
(12.0 – 16.0) |
21.1
(18.1 – 22.1) |
| +1 at 6A | 8.8 | 3.5 | 1.9 | 6.3 | 3.6 |
| -2 at 6A | <0.1* | <0.1* | <0.1* | 4.0 | 7.8 |
| Other -2 | 0.3 | <0.1* | 0.1* | 0.7 | 0.2* |
| Cins | 0.8 | 0.7 | 0.9 | 0.3 | 1.1 |
| Cdel | 0.3 | 0.1* | 0.1* | <0.1* | <0.2* |
| Large del | 0.8 | 0.4 | 3.3 | 0.1* | 4.2 |
| Others | 2.9 | 2.1 | 3.0 | 2.9 | 4.4 |
Reversion rates (× 10-10) were measured at 1000 ng/ml Dox.
*
Rates are considered unreliable as they are based on ≤1 event.
a
Endogenous location on chromosome II.