Table 3.
Rates of specific classes of frameshift mutations under high-transcription conditions
| Allele
Information |
pTET-lys2ΔA746 SAME |
pTET-lys2ΔA746 OPPOSITE |
pTET-lys2ΔA746 SAME rev3 |
pTET-lys2ΔA746 OPPOSITE rev3 |
pTET-lys2ΔA746 SAME rad14 |
pTET-lys2ΔA746 OPPOSITE rad14 |
|---|---|---|---|---|---|---|
| Total | 266
(237 – 284) |
226
(193 – 273) |
74.0
(49.8 – 112) |
76.4
(56.2 – 105) |
549
(488 – 601) |
566
(499 – 594) |
| +1 at 6A | 100 | 27.1 | 49.7 | 18.4 | 115 | 49.8 |
| -2 at 6A | 39.9 | 29.4 | 16.6 | 41.6 | 44.9 | 45.3 |
| Other -2 | 23.9 | 40.7 | 0.6* | 5.4 | 9.9 | 41.3 |
| Cins | 18.6 | 56.5 | <0.6* | <0.7* | 95 | 250.7 |
| Cdel | 8.0 | 20.3 | <0.6* | <0.7* | 14.8 | 36.8 |
| Large del | 2.7 | <2.0* | 1.9 | 4.1 | 4.9 | 31.7 |
| Others | 71.8 | 49.7 | 5.1 | 6.8 | 265 | 109.8 |
Reversion rates (× 10-10) measured at 0 ng/ml Dox.
*
Rates are considered unreliable as they are based on ≤1 event.