Figure 6.
Interactions of the exon 7 domain with nearby structural elements
Homology model of IFI in the pre-power-stroke state (ExPDB 1qvi: bound nucleotide is ADP-VO4), showing the exon 7 area (residues 301-335 in red), the relay area (magenta), switch I (green) and helix L (yellow). The highly conserved salt-bridge between exon 7 residue D327 and relay area residue R283 is indicated. Note the proximity of switch I toward the relay area. Interactions from the non-conserved exon 7 residues Y313 and D327 toward helix L (yellow) are also shown.