Figure 1.

Inhibition of proliferative responses of T cell lines specific to myasthenogenic peptides. Different concentrations of analog Lys-262–Ala-207 were added to (A) cultures of cells of the TCSJL195-212 line and 5 μM p195-212 or to (B) cells of the TCBALB/c259-271 line in the presence of 20 μM p259-271. After 48 hr of incubation, [³H]thymidine was added. Sixteen hours later, plates were harvested onto filter paper. Results are expressed as percent inhibition of the specific proliferative response of peptides p195-212 • (stimulation index = 43) or p259-271 ▪ (stimulation index = 79).