TABLE 3.

Mutation frequencies of pseudo-wild-type and intermediate alleles

Relevant genotype	CAN ratea	Fold induction CAN	FOA ratea	Fold induction FOA	Mismatch repair phenotypeb
msh2Δ	1.5 × 10−05	31	3.5 × 10−04	264	—
MSH2	4.8 × 10−07	1	1.3 × 10−06	1	+
msh2-Y104C	4.4 × 10−07	1	9.4 × 10−07	1	+
msh2-T44M	5.5 × 10−07	1	9.5 × 10−07	1	+
msh2-N123S	5.6 × 10−07	1	9.7 × 10−07	1	+
msh2-Q852E	8.3 × 10−07	2	1.1 × 10−06	1	+
msh2-G692S	6.7 × 10−07	1	1.4 × 10−06	1	+
msh2-I141M	7.6 × 10−07	2	1.5 × 10−06	1	+
msh2-R352H	5.1 × 10−07	1	1.6 ×10−06	1	+
msh2-D164H	8.3 × 10−07	2	1.9 × 10−06	1	+
msh2-A892G	7.7 × 10−07	2	2.3 × 10−06	2	+
msh2-G317D	6.7 × 10−07	1	2.5 × 10−06	2	+
msh2-Q63P	6.4 × 10−07	1	3.0 × 10−06	2	+
msh2-E580V	5.4 × 10−07	1	5.4 × 10−06	4	+/−
msh2-A733V	7.0 × 10−07	1	6.8 × 10−06	5	+/−
msh2-L402F	7.3 × 10−07	2	6.8 × 10−06	5	+/−
msh2-G122S	1.1 × 10−06	2	7.1 × 10−06	5	+/−
msh2-S318C	1.1 × 10−06	2	6.4 × 10−06	5	+/−
msh2-S318Y	9.9 × 10−07	2	1.0 × 10−05	7	+/−
msh2-E912G	1.1 × 10−06	2	9.0 × 10−06	7	+/−
msh2-K873E	3.4 × 10−06	7	1.5 × 10−05	11	−/+
msh2-T347I	3.8 × 10−06	8	1.8 × 10−05	14	−/+
msh2-M707I	2.4 × 10−06	5	2.1 × 10−05	16	−/+

^aRate, mutations per cell division.

^bMMR, mismatch repair phenotype; see Table 1 notes for definitions of designations.