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Surface features of the CARM1 active site. Features of the active site are coloured: the His415-Asp166 couple (yellow), C-extension (green) and aromatic residues from Tyr262 in the double-E hairpin and the PFFRY/THWY motifs (blue). A peptide sequence of histone H3 (Pro16-Arg17-Lys18) is modelled into the active site with reference to the structures of PRMT1 and PAD4.
